Enantioselective intramolecular aldehyde α-alkylation with simple olefins: direct access to homo-ene products.
نویسندگان
چکیده
A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asymmetric strategy toward the production of a wide range of formyl-substituted rings with alkene transposition. Conceptually, this novel mechanism allows direct access to "homo-ene"-type products.
منابع مشابه
Direct, enantioselective α-alkylation of aldehydes using simple olefins.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 135 25 شماره
صفحات -
تاریخ انتشار 2013