Enantioselective intramolecular aldehyde α-alkylation with simple olefins: direct access to homo-ene products.

نویسندگان

  • Robert J Comito
  • Fernanda G Finelli
  • David W C MacMillan
چکیده

A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asymmetric strategy toward the production of a wide range of formyl-substituted rings with alkene transposition. Conceptually, this novel mechanism allows direct access to "homo-ene"-type products.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 135 25  شماره 

صفحات  -

تاریخ انتشار 2013